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rdf:type |
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lifeskim:mentions |
umls-concept:C0017526,
umls-concept:C0017982,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0035820,
umls-concept:C0205263,
umls-concept:C0205419,
umls-concept:C0206464,
umls-concept:C0597357,
umls-concept:C1882417,
umls-concept:C2936413
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pubmed:dateCreated |
2008-2-21
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pubmed:abstractText |
We previously identified unusual variants of Moloney and Friend ecotropic mouse gammaretroviruses that have altered host range and are cytopathic in cells of the wild mouse species Mus dunni. Cytopathicity was attributed to different amino acid substitutions at the same critical env residue involved in receptor interaction: S82F in the Moloney variant Spl574, and S84A in the Friend mouse leukemia virus F-S MLV. Because M. dunni cells carry a variant CAT-1 cell surface virus receptor (dCAT-1), we examined the role of this receptor variant in cytopathicity and host range.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-10196270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-11559807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-12490395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-12502812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-12692209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-12932075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-1370096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-1433518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-15479849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-15507605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-167514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-1717711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-2836939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-4099080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-4291934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-6092693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-7933135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-8289366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-8382297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-8393858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-8445722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-8510216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-8794331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-9123877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186934-9287219
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1742-4690
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18186934-Animals,
pubmed-meshheading:18186934-Animals, Wild,
pubmed-meshheading:18186934-Cationic Amino Acid Transporter 1,
pubmed-meshheading:18186934-Cell Line,
pubmed-meshheading:18186934-Cytopathogenic Effect, Viral,
pubmed-meshheading:18186934-Friend murine leukemia virus,
pubmed-meshheading:18186934-Giant Cells,
pubmed-meshheading:18186934-Glycosylation,
pubmed-meshheading:18186934-Leukemia, Experimental,
pubmed-meshheading:18186934-Mice,
pubmed-meshheading:18186934-Moloney murine leukemia virus,
pubmed-meshheading:18186934-NIH 3T3 Cells,
pubmed-meshheading:18186934-Polymorphism, Genetic,
pubmed-meshheading:18186934-Retroviridae Infections,
pubmed-meshheading:18186934-Transfection,
pubmed-meshheading:18186934-Tumor Virus Infections,
pubmed-meshheading:18186934-Virus Internalization
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pubmed:year |
2008
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pubmed:articleTitle |
Role of receptor polymorphism and glycosylation in syncytium induction and host range variation of ecotropic mouse gammaretroviruses.
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pubmed:affiliation |
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, 20892-0460, USA. yyan@niaid.nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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