Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-2-15
pubmed:abstractText
It is increasingly clear that complex networks of relationships between genes and/or proteins govern neoplastic processes. Our understanding of these networks is expanded by the use of functional genomic and proteomic approaches in addition to computational modeling. Concurrently, whole-genome association scans and mutational screens of cancer genomes identify novel cancer genes. Together, these analyses have vastly increased our knowledge of cancer, in terms of both "part lists" and their functional associations. However, genetic interactions have hitherto only been studied in depth in model organisms and remain largely unknown for human systems. Here, we discuss the importance and potential benefits of identifying genetic interactions at the human genome level for creating a better understanding of cancer susceptibility and progression and developing novel effective anticancer therapies. We examine gene expression profiles in the presence and absence of co-amplification of the 8q24 and 20q13 chromosomal regions in breast tumors to illustrate the molecular consequences and complexity of genetic interactions and their role in tumorigenesis. Finally, we highlight current strategies for targeting tumor dependencies and outline potential matrix screening designs for uncovering molecular vulnerabilities in cancer cells.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-10436161, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-10647931, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-10802651, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-11232561, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-11357144, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-11404819, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-11431698, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-11743205, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-11867360, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-11872829, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-11872830, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-12086884, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-12351582, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-12584123, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-12668603, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-1365397, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-14585768, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-14614241, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-14614483, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-14735120, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-14735121, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-14764870, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-14993904, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-15042091, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-15305330, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-15451511, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-15473857, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-15496468, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-15592468, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-15608512, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-15687504, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-15829966, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-15829967, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-15833125, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-15877074, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-15920528, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-16001072, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-16027168, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-16155567, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-16169070, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-16189514, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-16200065, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-16420673, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-16421597, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-16527984, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-16845399, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-16854211, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-16899776, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-16907712, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-16956909, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-16990807, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17018584, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17157792, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17192061, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17293865, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17344846, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17379100, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17429401, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17434922, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17440825, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17449820, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17510664, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17512858, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17529967, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17529973, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17574021, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17584915, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17611206, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17634446, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17721534, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17872411, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-17922014, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-7545954, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-7939630, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-8524414, http://linkedlifedata.com/resource/pubmed/commentcorrection/18186929-8849441
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1476-4598
pubmed:author
More...