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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0022671,
umls-concept:C0030705,
umls-concept:C0035015,
umls-concept:C0035647,
umls-concept:C0205087,
umls-concept:C0205178,
umls-concept:C1337092,
umls-concept:C1413188,
umls-concept:C1522558,
umls-concept:C1548437,
umls-concept:C1556095,
umls-concept:C1705079,
umls-concept:C1882417,
umls-concept:C1882923
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-11
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pubmed:abstractText |
Among the factors modulating transplant rejection, chemokines and their respective receptors deserve special attention. Increased expression of monocyte chemoattractant protein-1 (MCP-1) and its corresponding receptor (chemokine receptor-2, CCR2) has been implicated in renal transplant rejection. To determine the impact of the MCP-1-2518G and CCR2-64I genotypes on renal allograft function, 167 Korean patients who underwent transplantation over a 25-year period were evaluated. Genomic DNA was genotyped using polymerase chain reaction followed by restriction fragment length polymorphism analysis. Fifty-five (32.9%) patients were homozygous for the MCP-1-2518G polymorphism. Nine (5.4%) patients were homozygous for the CCR2-64I polymorphism. None of the investigated polymorphism showed a significant shift in long-term allograft survival. However, a significant increase was noted for the risk of late acute rejection in recipients who were homozygous for the MCP-1-2518G polymorphism (OR, 2.600; 95% CI, 1.125-6.012; P = 0.022). There was also an association between the MCP-1-2518G/G genotype and the number of late acute rejection episodes (P = 0.024). Although there was no difference in the incidence of rejection among recipients stratified by the CCR2-V64I genotype, recipients with the CCR2-V64I GG genotype in combination with the MCP-1-2518G/G genotype had a significantly higher risk of acute or late acute rejection among the receptor-ligand combinations (P = 0.006, P = 0.008, respectively). The MCP-1 variant may be a marker for risk of late acute rejection in Korean patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-10362511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-10708134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-11063329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-11228176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-11239512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-11245782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-11336683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-11544006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-11856781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-12239249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-12460032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-15458467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-1738926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-7568006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-8076154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-8769141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-8940321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-9039933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-9133471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18186797-9252328
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1744-313X
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pubmed:author |
pubmed-author:IhmC GCG,
pubmed-author:JeongK HKH,
pubmed-author:JoyVV,
pubmed-author:KangS WSW,
pubmed-author:KimY HYH,
pubmed-author:KimY WYW,
pubmed-author:LeeS HSH,
pubmed-author:LeeT WTW,
pubmed-author:ParkS JSJ,
pubmed-author:SohnH SHS,
pubmed-author:YoonY CYC
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pubmed:issnType |
Electronic
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-31
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18186797-Adult,
pubmed-meshheading:18186797-Analysis of Variance,
pubmed-meshheading:18186797-Chemokine CCL2,
pubmed-meshheading:18186797-Female,
pubmed-meshheading:18186797-Graft Rejection,
pubmed-meshheading:18186797-Graft Survival,
pubmed-meshheading:18186797-Humans,
pubmed-meshheading:18186797-Kidney Transplantation,
pubmed-meshheading:18186797-Male,
pubmed-meshheading:18186797-Middle Aged,
pubmed-meshheading:18186797-Multivariate Analysis,
pubmed-meshheading:18186797-Polymorphism, Genetic,
pubmed-meshheading:18186797-Receptors, CCR2
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pubmed:year |
2008
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pubmed:articleTitle |
Association of MCP-1 and CCR2 polymorphisms with the risk of late acute rejection after renal transplantation in Korean patients.
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pubmed:affiliation |
Department of Nephrology, College of Medicine, Inje University, Busan, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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