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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-4-21
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pubmed:abstractText |
The presence of disseminated tumor cells in the bone marrow (DTC-BM) of breast cancer patients has shown independent prognostic impact. Immunomagnetic enrichment of such cells is an approach to increase the number of detected cells with limited sample volume, especially for circulating tumor cells (CTCs) in blood. The Thomsen-Friedenreich (TF) antigen (CD 176) is a specific oncofetal carbohydrate epitope (Galbeta1-3GalNAcalpha-O) expressed on the surface of various carcinomas. Own studies demonstrated a nearly complete TF expression on DTC-BM, indicating its suitability as marker for immunomagnetic enrichment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0262-0898
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
233-40
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18185913-Adult,
pubmed-meshheading:18185913-Aged,
pubmed-meshheading:18185913-Antigens, Tumor-Associated, Carbohydrate,
pubmed-meshheading:18185913-Bone Marrow,
pubmed-meshheading:18185913-Bone Marrow Examination,
pubmed-meshheading:18185913-Bone Marrow Neoplasms,
pubmed-meshheading:18185913-Breast Neoplasms,
pubmed-meshheading:18185913-Female,
pubmed-meshheading:18185913-Humans,
pubmed-meshheading:18185913-Immunoenzyme Techniques,
pubmed-meshheading:18185913-Immunomagnetic Separation,
pubmed-meshheading:18185913-Middle Aged,
pubmed-meshheading:18185913-Neoplastic Cells, Circulating,
pubmed-meshheading:18185913-Prognosis,
pubmed-meshheading:18185913-Tumor Markers, Biological
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pubmed:year |
2008
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pubmed:articleTitle |
Immunomagnetic enrichment of disseminated tumor cells in bone marrow and blood of breast cancer patients by the Thomsen-Friedenreich-Antigen.
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pubmed:affiliation |
First Department of Obstetrics & Gynecology, Ludwig Maximilians University of Munich, Munich, Germany. Christian.Schindlbeck@med.uni-muenchen.de
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pubmed:publicationType |
Journal Article
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