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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-4-29
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pubmed:abstractText |
The angiotensin type 1 receptor blocker (ARB) and peroxisome proliferator-activated receptor (PPAR) gamma modulator telmisartan has been recently demonstrated to reduce plasma triglycerides in nondiabetic and diabetic hypertensive patients. The present study investigates the molecular mechanisms of telmisartans hypolipidemic actions, in particular its effect on the PPARalpha pathway. RESEARCH DESIGN AND METHODS; Regulation of PPARalpha target genes by telmisartan was studied by real-time PCR and Western immunoblotting in vitro and in vivo in liver/skeletal muscle of mice with diet-induced obesity. Activation of the PPARalpha ligand binding domain (LBD) was investigated using transactivation assays.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1939-327X
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pubmed:author |
pubmed-author:BöhmChristianC,
pubmed-author:CaronSandrineS,
pubmed-author:ClemenzMarkusM,
pubmed-author:Foryst-LudwigAnnaA,
pubmed-author:FrostNikolajN,
pubmed-author:GustRonaldR,
pubmed-author:HartgeMartinM,
pubmed-author:KintscherUlrichU,
pubmed-author:SchuppMichaelM,
pubmed-author:StaelsBartB,
pubmed-author:UngerThomasT
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pubmed:issnType |
Electronic
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1405-13
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18184928-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:18184928-Animals,
pubmed-meshheading:18184928-Benzimidazoles,
pubmed-meshheading:18184928-Benzoates,
pubmed-meshheading:18184928-Cell Line,
pubmed-meshheading:18184928-Cell Line, Tumor,
pubmed-meshheading:18184928-Gene Expression Regulation,
pubmed-meshheading:18184928-Gene Silencing,
pubmed-meshheading:18184928-Genes, Reporter,
pubmed-meshheading:18184928-Humans,
pubmed-meshheading:18184928-Liver,
pubmed-meshheading:18184928-Liver Neoplasms,
pubmed-meshheading:18184928-Male,
pubmed-meshheading:18184928-Mice,
pubmed-meshheading:18184928-Mice, Inbred C57BL,
pubmed-meshheading:18184928-PPAR alpha,
pubmed-meshheading:18184928-Polymerase Chain Reaction,
pubmed-meshheading:18184928-RNA, Small Interfering,
pubmed-meshheading:18184928-Transcriptional Activation,
pubmed-meshheading:18184928-Transfection
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pubmed:year |
2008
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pubmed:articleTitle |
Liver-specific peroxisome proliferator-activated receptor alpha target gene regulation by the angiotensin type 1 receptor blocker telmisartan.
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pubmed:affiliation |
Center for Cardiovascular Research, Institute of Pharmacology, Charité-Universitätsmedizin Berlin, Hessische Str. 3-4, 10115 Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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