Source:http://linkedlifedata.com/resource/pubmed/id/18182807
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-1-9
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| pubmed:abstractText |
Uremia has been implicated in increased oxidative stress (OS) and decreased monocyte HLA-DR expression in chronic kidney disease (CKD) patients. Thus, one would expect normalization of these parameters after successful kidney transplant (KTx). Our aim was to describe patterns of OS and HLA-DR expression after KTx and to explore the effect of renal function and different immunosuppression regimens. 30 KTx patients (20 male; 48 +/- 11 years) were enrolled and compared with 20 healthy controls. We measured advanced oxidation protein products (AOPP) and the percentage of monocytes expressing HLA-DR (%DR+) before (preKTx) and after KTx (on days 2, 30, 90, 180 and after 1 year). Compared to controls, patients had a higher preKTx AOPP (152.6 vs. 69.3 micromol/l; p < 0.001). AOPP decreased at 48 h after KTx, achieving values similar to controls. Thereafter, it increased again and remained significantly higher compared to controls, returning to preKTx levels at 90 days. Prior to KTx there was a trend for lower %DR+ in KTx patients compared to controls (96 vs. 98%; NS). Following KTx, patients had a lower %DR+ in the 1st month; then it gradually returned to preKTx levels during the 1st year; at no time did it reach a value similar to controls. Cyclosporine (CyA)-treated patients had a significantly higher AOPP (161.5 vs. 99.5 micromol/l; p = 0.03) and a lower %DR+ (91.7 vs. 96.4; p < 0.05) at 30 days than patients on tacrolimus (FK). Patients on mycophenolate mofetil (MMF) showed a low AOPP (106.9 vs. 168.1 micromol/l; p = 0.05) and a high %DR+ (96.7 vs. 88.2%; p = 0.001) than those on everolimus. After 3 months, CyA-treated patients had a non-significant increase in AOPP levels, whereas those on FK showed a decrease (p < 0.05) as did those treated with MMF (p < 0.05). Successful KTx reduced but did not normalize AOPP, suggesting ongoing OS, perhaps due to persistent mild renal dysfunction and the effects of immunosuppression. HLA-DR expression remained low after KTx, which may be a possible contributing factor to infectious complications after transplantation. Immunosuppressive agents appear to have diverse effects on OS and HLA-DR expression.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Mycophenolic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus,
http://linkedlifedata.com/resource/pubmed/chemical/mycophenolate mofetil
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1421-9735
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| pubmed:author |
pubmed-author:BassoFlavioF,
pubmed-author:ChiaramonteStefanoS,
pubmed-author:CorradiValentinaV,
pubmed-author:CruzDinnaD,
pubmed-author:DissegnaDanielaD,
pubmed-author:GoepelVolkerV,
pubmed-author:LentiniPaoloP,
pubmed-author:NalessoFedericoF,
pubmed-author:RoncoClaudioC,
pubmed-author:SilvaSandraS,
pubmed-author:de CalMassimoM
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| pubmed:copyrightInfo |
(c) 2008 S. Karger AG, Basel.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
26
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
105-10
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:18182807-Adult,
pubmed-meshheading:18182807-Cyclosporine,
pubmed-meshheading:18182807-Female,
pubmed-meshheading:18182807-HLA-DR Antigens,
pubmed-meshheading:18182807-Humans,
pubmed-meshheading:18182807-Immunosuppression,
pubmed-meshheading:18182807-Immunosuppressive Agents,
pubmed-meshheading:18182807-Kidney,
pubmed-meshheading:18182807-Kidney Function Tests,
pubmed-meshheading:18182807-Kidney Transplantation,
pubmed-meshheading:18182807-Longitudinal Studies,
pubmed-meshheading:18182807-Male,
pubmed-meshheading:18182807-Middle Aged,
pubmed-meshheading:18182807-Monocytes,
pubmed-meshheading:18182807-Mycophenolic Acid,
pubmed-meshheading:18182807-Oxidative Stress,
pubmed-meshheading:18182807-Prospective Studies,
pubmed-meshheading:18182807-Renal Insufficiency,
pubmed-meshheading:18182807-Tacrolimus
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| pubmed:year |
2008
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| pubmed:articleTitle |
Oxidative stress and 'monocyte reprogramming' after kidney transplant: a longitudinal study.
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| pubmed:affiliation |
Department of Nephrology, Dialysis and Transplant, St. Bortolo Hospital, Vicenza, Italy.
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| pubmed:publicationType |
Journal Article
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