Source:http://linkedlifedata.com/resource/pubmed/id/18182070
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2008-4-30
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| pubmed:abstractText |
The literature surrounding rodent models of human anxiety disorders is discrepant concerning which models reflect anxiety-like behavior distinct from general activity and whether different models are measuring the same underlying constructs. This experiment compared the responses of 15 inbred mouse strains (129S1/SvlmJ, A/J, AKR/J, BALB/cByJ, C3H/HeJ, C57BL/6J, C57L/J, CBA/J, CE/J, DBA/2J, FVB/NJ, NZB/B1NJ, PL/J, SJL/J and SWR/J) in three anxiety-like behavioral tasks (light/dark test, elevated zero-maze and open field) to examine whether responses were phenotypically and/or genetically correlated across tasks. Significant strain differences were found for all variables examined. Principal components analyses showed that variables associated with both activity and anxiety-like behaviors loaded onto one factor, while urination and defecation loaded onto another factor. Our findings differ from previous research by suggesting that general activity and anxiety-related behaviors are linked, negatively correlated and cannot easily be dissociated in these assays. However, these findings may not necessarily generalize to other unconditioned anxiety-like behavioral tests.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1601-183X
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
7
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
496-505
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| pubmed:meshHeading |
pubmed-meshheading:18182070-Animals,
pubmed-meshheading:18182070-Anxiety,
pubmed-meshheading:18182070-Anxiety Disorders,
pubmed-meshheading:18182070-Behavior, Animal,
pubmed-meshheading:18182070-Defecation,
pubmed-meshheading:18182070-Disease Models, Animal,
pubmed-meshheading:18182070-Exploratory Behavior,
pubmed-meshheading:18182070-Fear,
pubmed-meshheading:18182070-Female,
pubmed-meshheading:18182070-Genetic Predisposition to Disease,
pubmed-meshheading:18182070-Male,
pubmed-meshheading:18182070-Maze Learning,
pubmed-meshheading:18182070-Mice,
pubmed-meshheading:18182070-Mice, Inbred Strains,
pubmed-meshheading:18182070-Motor Activity,
pubmed-meshheading:18182070-Neuropsychological Tests,
pubmed-meshheading:18182070-Phenotype,
pubmed-meshheading:18182070-Principal Component Analysis,
pubmed-meshheading:18182070-Species Specificity,
pubmed-meshheading:18182070-Urination
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| pubmed:year |
2008
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| pubmed:articleTitle |
Three murine anxiety models: results from multiple inbred strain comparisons.
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| pubmed:affiliation |
Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health & Science University, VA Medical Center, Portland, OR 97239, USA. milnerl@ohsu.edu
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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