Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-1-16
pubmed:abstractText
We examined the brain expression patterns of zebrafish genes Lhx6, Lhx7, Dlx2a, GAD67, and Tbr2/eomesa; except for GAD67, expression domains are restricted to the forebrain. In particular, a distribution of transcripts in the early zebrafish telencephalon comparable to that of tetrapods is revealed. Expression domains of Lhx6 and Lhx7 are restricted to a ventral subdivision (Sdv) of the precommissural dorsal subpallium, interpreted here as the homologue of the mammalian medial ganglionic eminence (the adult pallidum in mammals). In contrast, there is no such expression in the dorsal subdivision (Sdd) of the dorsal subpallium, interpreted here as the homologue of the mammalian lateral ganglionic eminence (the adult caudatoputamen in mammals). The Lhx6 and Lhx7 genes are furthermore expressed in the zebrafish ventral subpallium (Sv, septum), and in the supra-/postcommissurally lying posterior subdivision of the dorsal subpallium (Sdp; possible homologue of the subpallial amygdala). Also in support of this comparative interpretation, Dlx2a is generally expressed in all of the subpallium, including the ventricular zones of (all three subvidisions of) the dorsal as well as of the ventral subpallium. In contrast, Tbr2 is expressed in all of the zebrafish pallium and in a restricted zone of the ventral subpallium, comparable to the known restricted septal expression in mammals. The telencephalic expression of GAD67 largely coincides with that of Dlx2a. However, GAD67-positive cells migrate (radially) into postmitotic zones of the peripheral subpallium (as does Dlx2a and Lhx6) as well as (tangentially) into pallial zones (as does Dlx2a, but not Lhx6).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface, http://linkedlifedata.com/resource/pubmed/chemical/Eomes protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Glutamate Decarboxylase, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/LHX6 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/LIM homeobox protein 8, http://linkedlifedata.com/resource/pubmed/chemical/LIM-Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/T-Box Domain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins, http://linkedlifedata.com/resource/pubmed/chemical/antigen Dlx-2, http://linkedlifedata.com/resource/pubmed/chemical/glutamate decarboxylase 1
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1096-9861
pubmed:author
pubmed:copyrightInfo
(c) 2008 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:day
10
pubmed:volume
507
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1245-57
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:18181142-Animals, pubmed-meshheading:18181142-Antigens, Surface, pubmed-meshheading:18181142-Basal Ganglia, pubmed-meshheading:18181142-Biological Evolution, pubmed-meshheading:18181142-Body Patterning, pubmed-meshheading:18181142-Gene Expression Regulation, Developmental, pubmed-meshheading:18181142-Glutamate Decarboxylase, pubmed-meshheading:18181142-Homeodomain Proteins, pubmed-meshheading:18181142-In Situ Hybridization, pubmed-meshheading:18181142-LIM-Homeodomain Proteins, pubmed-meshheading:18181142-Nerve Tissue Proteins, pubmed-meshheading:18181142-RNA, Messenger, pubmed-meshheading:18181142-Sequence Homology, Nucleic Acid, pubmed-meshheading:18181142-Species Specificity, pubmed-meshheading:18181142-T-Box Domain Proteins, pubmed-meshheading:18181142-Transcription Factors, pubmed-meshheading:18181142-Zebrafish, pubmed-meshheading:18181142-Zebrafish Proteins
pubmed:year
2008
pubmed:articleTitle
Early teleostean basal ganglia development visualized by zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression.
pubmed:affiliation
Department of Biopharmaceutical Sciences and Programs in Human Genetics, University of California, San Francisco, California 94143-2811, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural