Source:http://linkedlifedata.com/resource/pubmed/id/18180403
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2008-1-24
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| pubmed:abstractText |
Oxidative stress plays an important role in the development of cardiac remodeling after myocardial infarction (MI), but the sources of oxidative stress remain unclear. We investigated the role of Nox2-containing reduced nicotinamide-adenine dinucleotide phosphate oxidase in the development of cardiac remodeling after MI. Adult Nox2(-/-) and matched wild-type (WT) mice were subjected to coronary artery ligation and studied 4 weeks later. Infarct size after MI was similar in Nox2(-/-) and WT mice. Nox2(-/-) mice exhibited significantly less left ventricular (LV) cavity dilatation and dysfunction after MI than WT mice (eg, echocardiographic LV end-diastolic volume: 75.7+/-5.8 versus 112.4+/-12.3 microL; ejection fraction: 41.6+/-3.7 versus 32.9+/-3.2%; both P<0.05). Similarly, in vivo LV systolic and diastolic functions were better preserved in Nox2(-/-) than WT mice (eg, LV dP/dt(max): 7969+/-385 versus 5746+/-234 mm Hg/s; LV end-diastolic pressure: 12.2+/-1.3 versus 18.0+/-1.8 mm Hg; both P<0.05). Nox2(-/-) mice exhibited less cardiomyocyte hypertrophy, apoptosis, and interstitial fibrosis; reduced increases in expression of connective tissue growth factor and procollagen 1 mRNA; and smaller increases in myocardial matrix metalloproteinase-2 activity than WT mice. These data suggest that the Nox2-containing reduced nicotinamide-adenine dinucleotide phosphate oxidase contributes significantly to the processes underlying adverse cardiac remodeling and contractile dysfunction post-MI.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-nitrotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Cybb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Nox4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1524-4563
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
51
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
319-25
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| pubmed:meshHeading |
pubmed-meshheading:18180403-Animals,
pubmed-meshheading:18180403-Apoptosis,
pubmed-meshheading:18180403-Cardiomegaly,
pubmed-meshheading:18180403-Echocardiography,
pubmed-meshheading:18180403-Fibrosis,
pubmed-meshheading:18180403-Heart Catheterization,
pubmed-meshheading:18180403-Matrix Metalloproteinase 2,
pubmed-meshheading:18180403-Membrane Glycoproteins,
pubmed-meshheading:18180403-Mice,
pubmed-meshheading:18180403-Mice, Knockout,
pubmed-meshheading:18180403-Myocardial Infarction,
pubmed-meshheading:18180403-Myocardium,
pubmed-meshheading:18180403-NADPH Oxidase,
pubmed-meshheading:18180403-RNA, Messenger,
pubmed-meshheading:18180403-Staining and Labeling,
pubmed-meshheading:18180403-Survival Analysis,
pubmed-meshheading:18180403-Tyrosine,
pubmed-meshheading:18180403-Ventricular Remodeling
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| pubmed:year |
2008
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| pubmed:articleTitle |
Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction.
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| pubmed:affiliation |
Department of Cardiology, King's College London School of Medicine, James Black Centre, 125 Coldharbour Ln, London SE5 9NU, United Kingdom.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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