Linked Life Data

18180186

Source:http://linkedlifedata.com/resource/pubmed/id/18180186

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-6-9
pubmed:abstractText
Reduced efficacy of opioid analgesics in some abnormal pain states is a common clinical observation. We tested whether the depressing effect of spinally administered morphine (MOR) on C fibre-evoked spinal field potentials is diminished during long-term potentiation (LTP) induced in the spinal dorsal horn by high-frequency stimulation (HFS). MOR distinctly reduced evoked field potentials 2 h after LTP induction, yet MOR doses suppressing spinal responses in control rats (500 microM) failed to achieve so in HFS-receiving rats. However, HFS and MOR administration at the 0.01-0.1 mM range were found to interact positively as independent variables, suggesting that LTP induction may trigger an endogenous factor enhancing the effectiveness of spinally applied MOR. The present findings suggest that LTP-like, long-lasting enhancement of synaptic strength in the spinal dorsal horn can contribute to increasing MOR doses required for antinociception in some forms of abnormal pain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1532-2149
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
814-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Non-linear morphine-induced depression of spinal excitation following long-term potentiation of C fibre-evoked spinal field potentials.
pubmed:affiliation
Department of Neurosciences, School of Medicine and Dentistry, Basque Country University, Barrio Sarriena s/n, 48940 Leioa, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't