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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-2-5
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pubmed:abstractText |
We designed and synthesized a series of indole-2-amide-based compounds that antagonize interaction between the Dishevelled (Dvl) PDZ domain and a peptide derived from the natural PDZ ligand Frizzled-7 (Fz7). These compounds inhibit Tcf-mediated transcription activated by exogenous Dvl via the biochemical antagonism. We confirmed tumor cell-selective activation of caspases by these compounds.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
946-9
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pubmed:meshHeading |
pubmed-meshheading:18180158-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:18180158-Amides,
pubmed-meshheading:18180158-Apoptosis,
pubmed-meshheading:18180158-Combinatorial Chemistry Techniques,
pubmed-meshheading:18180158-Humans,
pubmed-meshheading:18180158-Indoles,
pubmed-meshheading:18180158-Models, Molecular,
pubmed-meshheading:18180158-Molecular Structure,
pubmed-meshheading:18180158-PDZ Domains,
pubmed-meshheading:18180158-Phosphoproteins,
pubmed-meshheading:18180158-Structure-Activity Relationship,
pubmed-meshheading:18180158-TCF Transcription Factors,
pubmed-meshheading:18180158-Transcription, Genetic,
pubmed-meshheading:18180158-Wnt Proteins
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pubmed:year |
2008
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pubmed:articleTitle |
Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity.
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pubmed:affiliation |
Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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