Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-1-18
pubmed:abstractText
The interleukin (IL) -23/IL-17 cytokine axis has been suggested to play an important role in the development of several autoimmune diseases including multiple sclerosis. Here, we compared the prevalence of C2370A single nucleotide polymorphism (SNP) in the 3' untranslated region (3'UTR) of the IL-23 receptor (IL23R) between 223 patients with relapsing-remitting multiple sclerosis (RRMS) and 200 healthy controls. The A2370A genotype was significantly over-represented among patients with RRMS (10.8%) and RRMS exhibiting oligoclonal bands in the cerebrospinal fluid (12.9%) when compared to healthy subjects (5.50%). Multiple regression analysis revealed that presence of AA genotype provides a two-fold risk for the development of multiple sclerosis (OR=2.072, 95% CI: 0.988-4.347, p<0.05). These data indicate that IL23R represents a novel shared susceptibility gene as its association with inflammatory bowel disease (IBD) has recently been verified.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
431
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
36-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:18180107-3' Untranslated Regions, pubmed-meshheading:18180107-Adult, pubmed-meshheading:18180107-Amino Acid Substitution, pubmed-meshheading:18180107-Biological Markers, pubmed-meshheading:18180107-DNA Mutational Analysis, pubmed-meshheading:18180107-Female, pubmed-meshheading:18180107-Gene Frequency, pubmed-meshheading:18180107-Genetic Markers, pubmed-meshheading:18180107-Genetic Predisposition to Disease, pubmed-meshheading:18180107-Genetic Testing, pubmed-meshheading:18180107-Genotype, pubmed-meshheading:18180107-Humans, pubmed-meshheading:18180107-Inflammatory Bowel Diseases, pubmed-meshheading:18180107-Interleukin-23, pubmed-meshheading:18180107-Male, pubmed-meshheading:18180107-Multiple Sclerosis, Relapsing-Remitting, pubmed-meshheading:18180107-Oligoclonal Bands, pubmed-meshheading:18180107-Polymorphism, Single Nucleotide, pubmed-meshheading:18180107-Regression Analysis, pubmed-meshheading:18180107-Risk Factors
pubmed:year
2008
pubmed:articleTitle
3'UTR C2370A allele of the IL-23 receptor gene is associated with relapsing-remitting multiple sclerosis.
pubmed:affiliation
Department of Neurology, University of Pecs, Rét u. 2, 7623 Pecs, Hungary. zsolt.illes@aok.pte.hu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't