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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-8
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pubmed:abstractText |
Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, used routinely in patients with coronary disease, can improve endothelial function but can have biphasic and dose-dependent effects on angiogenesis. In vitro evidence suggests that the proangiogenic effects of statins are linked to activation of Akt, a mediator of endothelial cell survival and an activator of endothelial nitric oxide synthase. We investigated the functional and molecular effects of atorvastatin supplementation on microvascular function and the endogenous angiogenic response to chronic myocardial ischemia in normocholesterolemic swine.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1097-685X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
117-22
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pubmed:dateRevised |
2010-12-28
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pubmed:meshHeading |
pubmed-meshheading:18179927-Animals,
pubmed-meshheading:18179927-Cholesterol,
pubmed-meshheading:18179927-Collateral Circulation,
pubmed-meshheading:18179927-Coronary Circulation,
pubmed-meshheading:18179927-Female,
pubmed-meshheading:18179927-Heptanoic Acids,
pubmed-meshheading:18179927-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:18179927-Male,
pubmed-meshheading:18179927-Microcirculation,
pubmed-meshheading:18179927-Myocardial Ischemia,
pubmed-meshheading:18179927-Neovascularization, Physiologic,
pubmed-meshheading:18179927-Pyrroles,
pubmed-meshheading:18179927-Swine
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pubmed:year |
2008
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pubmed:articleTitle |
Atorvastatin impairs the myocardial angiogenic response to chronic ischemia in normocholesterolemic swine.
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pubmed:affiliation |
Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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