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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-4-25
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pubmed:abstractText |
High mobility group box chromosomal protein 1 (HMGB1) is a nuclear protein that acts as a pro-inflammatory mediator following extracellular release. The protein is aberrantly expressed extracellularly in the settings of clinical and experimental synovitis. Therapy based on HMGB1 antagonists has shown encouraging results in experimental arthritis and warrants further scientific exploration using independent methods. In the present study we asked whether nuclear sequestration of HMGB1 preventing HMGB1 release would be beneficial for synovitis treatment.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-10409715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-10460158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-10952726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-1122133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-11257120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-11500360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-12070776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-12110890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-12231511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-12384917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-12604365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-12687539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-12794838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-12847700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-14532127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-15644117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-15802534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-15841214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-15899032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-16609041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-16855214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-16858429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-16879225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-1694131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-16966386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-16980509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-17114460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-17203009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-17397533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-17597834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-17667523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-17913975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-537911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18179697-7538298
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1478-6362
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R1
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18179697-Animals,
pubmed-meshheading:18179697-Arthritis, Experimental,
pubmed-meshheading:18179697-Cartilage, Articular,
pubmed-meshheading:18179697-Cell Nucleus,
pubmed-meshheading:18179697-Cell Proliferation,
pubmed-meshheading:18179697-Cells, Cultured,
pubmed-meshheading:18179697-Collagen Type II,
pubmed-meshheading:18179697-HMGB1 Protein,
pubmed-meshheading:18179697-Injections, Intraperitoneal,
pubmed-meshheading:18179697-Lymph Nodes,
pubmed-meshheading:18179697-Macrophages,
pubmed-meshheading:18179697-Mice,
pubmed-meshheading:18179697-Mice, Inbred DBA,
pubmed-meshheading:18179697-Organoplatinum Compounds,
pubmed-meshheading:18179697-Ovalbumin,
pubmed-meshheading:18179697-Synovitis,
pubmed-meshheading:18179697-T-Lymphocytes,
pubmed-meshheading:18179697-Time Factors,
pubmed-meshheading:18179697-Tissue Distribution
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pubmed:year |
2008
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pubmed:articleTitle |
Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis.
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pubmed:affiliation |
Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet/Karolinska University Hospital, 171 176 Stockholm, Sweden. Therese.Ostberg@ki.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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