Source:http://linkedlifedata.com/resource/pubmed/id/18177784
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2008-1-7
|
| pubmed:abstractText |
In clinical trials, patients become available for treatment sequentially. Especially in trials with a small number of patients, loss of power may become an important issue, if treatments are not allocated equally or if prognostic factors differ between the treatment groups. We present a new algorithm for sequential allocation of two treatments in small clinical trials, which is concerned with the reduction of both selection bias and imbalance.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0895-4356
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
61
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
119-24
|
| pubmed:meshHeading |
pubmed-meshheading:18177784-Algorithms,
pubmed-meshheading:18177784-Humans,
pubmed-meshheading:18177784-Patient Selection,
pubmed-meshheading:18177784-Prognosis,
pubmed-meshheading:18177784-Random Allocation,
pubmed-meshheading:18177784-Randomized Controlled Trials as Topic,
pubmed-meshheading:18177784-Research Design,
pubmed-meshheading:18177784-Selection Bias
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
New algorithm for treatment allocation reduced selection bias and loss of power in small trials.
|
| pubmed:affiliation |
Department of Neurology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands. j.hofmeijer@umcutrecht.nl
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|