Linked Life Data

18177748

Source:http://linkedlifedata.com/resource/pubmed/id/18177748

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-3-17
pubmed:abstractText
In this study we show that GATA-6 is a novel repressor of TN-C gene expression. We demonstrated that overexpression of GATA-6 in fibroblasts inhibited basal levels, as well as markedly decreased IL-4- and TGF-beta-induced TN-C mRNA and protein levels. A GATA-6 response element was mapped to position -467 to -460 of the TN-C promoter. In addition, we showed that GATA-6 binds this site both in vitro and in vivo.
pubmed:grant
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:volume
1779
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-51
pubmed:dateRevised
2011-4-28
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
GATA-6 is a novel transcriptional repressor of the human Tenascin-C gene expression in fibroblasts.
pubmed:affiliation
Division of Rheumatology and Immunology, Medical University of South Carolina, CSB 912, SC 29425-2229, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural