Linked Life Data

18176114

Source:http://linkedlifedata.com/resource/pubmed/id/18176114

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-1-7
pubmed:abstractText
The goals of this study were to determine whether alpha-tocopherol ether-linked acetic acid analog (alpha-TEA), a novel vitamin E analog, and celecoxib, alone or in combination, when administered as a late intervention can reduce the ultraviolet-induced nonmelanoma skin-tumor burden of established tumors, prevent additional tumors from developing, and prevent tumor recurrence once treatments are stopped. Hairless SKH-1 female mice were ultraviolet-irradiated for 24 weeks, divided into treatment groups so that each group had approximately 5.8 tumors/mouse, and then treated with 72 mug of liposome-formulated alpha-TEA by aerosol inhalation, 500 p.p.m. celecoxib in AIN-76 A diet, or a combination of alpha-TEA and celecoxib for 4 weeks. At the end of 4 weeks of treatment, each treatment group was subdivided, with one subgroup continuing to receive treatment and with treatment being stopped in the other. Skin-tumor development was monitored visually throughout the study and by histologic evaluation at the end. After 4 weeks of treatment, all treatments showed statistically significant reductions in tumor number when compared with controls. After termination of treatment, only alpha-TEA prevented a significant increase in tumor recurrence; however, continuous combination treatment resulted in the lowest total number of tumors. In conclusion alpha-TEA is an effective late-stage chemopreventive agent for nonmelanoma skin cancer that exhibits lasting benefits.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0959-4973
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-81
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:18176114-Acetic Acids, pubmed-meshheading:18176114-Administration, Inhalation, pubmed-meshheading:18176114-Animals, pubmed-meshheading:18176114-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:18176114-Carcinoma, pubmed-meshheading:18176114-Cyclooxygenase Inhibitors, pubmed-meshheading:18176114-Liposomes, pubmed-meshheading:18176114-Mice, pubmed-meshheading:18176114-Mice, Hairless, pubmed-meshheading:18176114-Neoplasm Recurrence, Local, pubmed-meshheading:18176114-Neoplasms, Radiation-Induced, pubmed-meshheading:18176114-Neoplasms, Squamous Cell, pubmed-meshheading:18176114-Pyrazoles, pubmed-meshheading:18176114-Radiation Dosage, pubmed-meshheading:18176114-Skin, pubmed-meshheading:18176114-Skin Neoplasms, pubmed-meshheading:18176114-Sulfonamides, pubmed-meshheading:18176114-Time Factors, pubmed-meshheading:18176114-Tocopherols, pubmed-meshheading:18176114-Treatment Outcome, pubmed-meshheading:18176114-Ultraviolet Rays
pubmed:year
2008
pubmed:articleTitle
Vitamin E analog, alpha-tocopherol ether-linked acetic acid analog, alone and in combination with celecoxib, reduces multiplicity of ultraviolet-induced skin cancers in mice.
pubmed:affiliation
Section of Molecular Genetics and Microbiology, The University of Texas, Austin, TX 78712, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural