Linked Life Data

1817554

Source:http://linkedlifedata.com/resource/pubmed/id/1817554

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1992-7-10
pubmed:abstractText
The murine class II genes are contained in the I region of the major histocompatibility complex (MHC). In the mouse, there are seven class II genes: A beta 3, A beta 2, A beta, E beta, E beta 2, A alpha, and E alpha. The A beta and A alpha genes code for the two polypeptide chains that form the I-A immune response molecule. The E beta and E alpha genes code for the two polypeptide chains that form the I-E immune response molecule. This review covers the genetic organization of the I region and the exon-intron structure of the class II genes. This review also discusses site-directed mutagenesis and exon shuffling studies and the effect of these changes on the function of Ia genes. Regulation of the cellular expression of Ia genes is discussed with emphasis on recent studies involving class II transgenic mice. Also, studies mapping recombination hotspots within the E alpha and E beta genes are reviewed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1040-8401
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-94
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Molecular biology of murine MHC class II genes.
pubmed:affiliation
Department of Medical Microbiology and Immunology, Ohio State University, Columbus 43210.
pubmed:publicationType
Journal Article, Review