Linked Life Data

18175096

Source:http://linkedlifedata.com/resource/pubmed/id/18175096

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
182
pubmed:dateCreated
2008-1-4
pubmed:abstractText
It is today generally accepted that anesthetics act by binding directly to sensitive target proteins. For certain intravenous anesthetics, such as propofol, barbiturates, and etomidate, the major target for anesthetic effect has been identified as the gamma-aminobutyric acid type A (GABA(A)) receptor, with particular subunits playing a crucial role. Etomidate, an intravenous imidazole general anesthetic, is thought to produce anesthesia by modulating or activating ionotropic Cl(-)-permeable GABA(A) receptors. For the less potent steroid anesthetic agents the picture is less clear, although a relatively small number of targets have been identified as being the most likely candidates. In this review, we summarize the most relevant clinical and experimental pharmacological properties of these intravenous anesthetics, the molecular targets mediating other endpoints of the anesthetic state in vivo, and the work that led to the identification of the GABA(A) receptor as the key target for etomidate and aminosteroids.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0171-2004
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
267-82
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Etomidate and other non-barbiturates.
pubmed:affiliation
Department of Anesthesiology, University of Brussels V.U.B. Medical Center, Laarbeeklaan 101, B-1090, Brussels, Belgium. anesvec@uzbrussel.be
pubmed:publicationType
Journal Article, Review