Linked Life Data

18172886

Source:http://linkedlifedata.com/resource/pubmed/id/18172886

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-7-28
pubmed:abstractText
To search for genes whose products modify aryl hydrocarbon receptor (AhR)-dependent toxicity caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), gene expression profiles in the liver were surveyed using microarrays 24 h after the administration of TCDD to three strains of female mice, BALB/cAnN (BALB), C3H/HeN (C3H) and CBA/JN (CBA) all of identical AhR genotype. The BALB/cAnN strain had a more marked induction of a number of glutathione S-transferase (GST) sub-families, particularly the GSTmicro gene family, compared with the other two strains. To assess the effects of GSTs induction to metabolize carcinogens, TCDD (40 microg kg(-1)) was administered to BALB and CBA strains, followed 24 h later by an i.p. injection of low or high dose of benzo[a]pyrene (B[a]P, 50 or 200 mg kg(-1)). The 32P-postlabelling analysis showed that administration of TCDD alone failed to induce DNA adduct formation in both BALB and CBA strain mouse livers. The low dose of B[a]P alone produced DNA adduct in the liver of both strains to a similar extent. Treatment with TCDD 24 h before the low dose of B[a]P suppressed the formation of B[a]P-induced DNA-adduct more markedly in the BALB strain compared with the CBA strain. Taken together, these findings show that TCDD treatment causes strain-specific alterations in gene expression and B[a]P-induced DNA adduct formation in the liver of female mice of the same AhRb2 genotype. Furthermore, it suggests that TCDD-treated female mice of the BALB strain may have genes whose products modify the toxicity of B[a]P as evidenced by TCDD-induced alterations in B[a]P-DNA adduct formation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0260-437X
pubmed:author
pubmed:copyrightInfo
Copyright 2008 John Wiley & Sons, Ltd.
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
724-33
pubmed:meshHeading
pubmed-meshheading:18172886-Animals, pubmed-meshheading:18172886-Benzo(a)pyrene, pubmed-meshheading:18172886-DNA Adducts, pubmed-meshheading:18172886-DNA Primers, pubmed-meshheading:18172886-Environmental Pollutants, pubmed-meshheading:18172886-Female, pubmed-meshheading:18172886-Gene Expression, pubmed-meshheading:18172886-Genotype, pubmed-meshheading:18172886-Liver, pubmed-meshheading:18172886-Mice, pubmed-meshheading:18172886-Mice, Inbred BALB C, pubmed-meshheading:18172886-Mice, Inbred C3H, pubmed-meshheading:18172886-Mice, Inbred CBA, pubmed-meshheading:18172886-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:18172886-Receptors, Aryl Hydrocarbon, pubmed-meshheading:18172886-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:18172886-Species Specificity, pubmed-meshheading:18172886-Tetrachlorodibenzodioxin
pubmed:year
2008
pubmed:articleTitle
Differences in gene expression and benzo[a]pyrene-induced DNA adduct formation in the liver of three strains of female mice with identical AhRb2 genotype treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and/or benzo[a]pyrene.
pubmed:affiliation
School of Public Health, Fudan University, 130 Dongan Road, Shanghai 200032, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't