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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-3
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pubmed:abstractText |
Long-standing ulcerative colitis (UC) predisposes patients to the development of colorectal cancer, but surveillance of colitis-associated cancer by detecting the precancerous lesion dysplasia is often difficult because of its rare occurrence and normal-looking appearance. In sporadic colorectal cancer, aberrant crypt foci (ACF) have been reported by many investigators to be precursor lesions of the adenoma-carcinoma sequence. In the present study, we analyzed the genetic background of ACF to determine whether they could be precursors for dysplasia, and we examined the usefulness of endoscopic examination of ACF as a surrogate marker for surveillance of colitis-associated cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:KatoJunjiJ,
pubmed-author:KatsukiShinichiS,
pubmed-author:KukitsuTakehiroT,
pubmed-author:MatsunagaTakuyaT,
pubmed-author:MiyanishiKojiK,
pubmed-author:NiitsuYoshiroY,
pubmed-author:NobuokaAtsushiA,
pubmed-author:SakamakiSumioS,
pubmed-author:SatoYasushiY,
pubmed-author:SonodaTomokoT,
pubmed-author:TakayamaTetsujiT,
pubmed-author:TakimotoRishuR
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
14
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
48-54
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pubmed:meshHeading |
pubmed-meshheading:18172251-Adult,
pubmed-meshheading:18172251-Colitis, Ulcerative,
pubmed-meshheading:18172251-Colorectal Neoplasms,
pubmed-meshheading:18172251-Disease Progression,
pubmed-meshheading:18172251-Endoscopy, Gastrointestinal,
pubmed-meshheading:18172251-Female,
pubmed-meshheading:18172251-Genes, APC,
pubmed-meshheading:18172251-Genes, p16,
pubmed-meshheading:18172251-Genes, p53,
pubmed-meshheading:18172251-Genes, ras,
pubmed-meshheading:18172251-Humans,
pubmed-meshheading:18172251-Male,
pubmed-meshheading:18172251-Mutation,
pubmed-meshheading:18172251-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:18172251-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:18172251-Precancerous Conditions,
pubmed-meshheading:18172251-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2008
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pubmed:articleTitle |
Aberrant crypt foci as precursors of the dysplasia-carcinoma sequence in patients with ulcerative colitis.
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pubmed:affiliation |
Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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