Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-1-3
pubmed:abstractText
Nascent transcription occurs at nuclear foci of concentrated, hyperphosphorylated RNA polymerase II (RNAPII). We investigate RNAPII localization, distal gene co-association, and Hbb locus conformation during inhibition of transcription. Our results show distal active genes remain associated with RNAPII foci and each other in the absence of elongation. When initiation is inhibited, active genes dissociate from RNAPII foci and each other, suggesting initiation is necessary to tether distal active genes to shared foci. In the absence of transcription RNAPII foci remain, indicating they are not simple accumulations of RNAPII on transcribed genes but exist as independent nuclear subcompartments.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-10409729, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-10751148, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-10882078, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-10882079, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-11030652, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-11389446, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-11854306, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-12410231, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-12426570, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-12473686, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-12504019, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-14517543, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-15155579, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-15300240, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-15361872, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-15502823, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-15861303, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-16105879, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-16705039, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-16751176, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-16949370, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-17033623, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-17307818, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-17622196, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-2990913, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-6204996, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-643052, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-7557375, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-7694722, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-7759473, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-8320255, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-8458323, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-8612682, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-8900211, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-8972849, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-9774345, http://linkedlifedata.com/resource/pubmed/commentcorrection/18172162-9809066
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0890-9369
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
20-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Transcription factories are nuclear subcompartments that remain in the absence of transcription.
pubmed:affiliation
Laboratory of Chromatin and Gene Expression, The Babraham Institute, Cambridge CB22 3AT, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't