Linked Life Data

1817025

Source:http://linkedlifedata.com/resource/pubmed/id/1817025

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
1992-7-9
pubmed:abstractText
Neuropathological features of late onset gangliosidoses are reviewed. Although neuropathological studies are carried out on limited numbers of late onset cases, it appears that electron-dense heterogeneous conglomerates of neuronal inclusions increased with age admixed with more typical membranous cytoplasmic inclusions of gangliosidosis. Unlike early onset cases, which show extensive storage in cerebral cortical neurons, cortical neurons are involved less in late onset cases. In chronic (or adult) GM1 gangliosidosis, neuronal storage is almost exclusively limited to the basal ganglia, while in chronic (or adult) GM2 gangliosidosis storage neurons are more widely distributed in the thalamus, substantia nigra and other brainstem nuclei, and cerebellum is significantly affected.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0378-5866
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-10
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Neuropathology of late onset gangliosidoses. A review.
pubmed:affiliation
Department of Pathology (Neuropathology), University of North Carolina, Chapel Hill.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Review