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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-2-11
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pubmed:abstractText |
The anti-plasmodial activity of Ailanthus excelsa stem bark was investigated. The methanolic extract inhibited in vitro growth of chloroquine-sensitive (D10) and resistant strains (W2) of Plasmodium falciparum (IC50 4.6 and 2.8 microg/ml, respectively). The effect was retained in the chloroform fraction (3.1 and 2.1 microg/ml, respectively). The anti-plasmodial activity could be ascribed to the impairment of haemoglobin degradation through the inhibition of plasmepsin II activity (IC50 of 13.43+/-1.74 microg/ml) and of the haem detoxification to haemozoin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0367-326X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18166279-Ailanthus,
pubmed-meshheading:18166279-Animals,
pubmed-meshheading:18166279-Aspartic Acid Endopeptidases,
pubmed-meshheading:18166279-Chloroquine,
pubmed-meshheading:18166279-Drug Resistance,
pubmed-meshheading:18166279-Erythrocytes,
pubmed-meshheading:18166279-Hemeproteins,
pubmed-meshheading:18166279-Plant Bark,
pubmed-meshheading:18166279-Plant Extracts,
pubmed-meshheading:18166279-Plasmodium falciparum,
pubmed-meshheading:18166279-Protozoan Proteins
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pubmed:year |
2008
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pubmed:articleTitle |
Anti-plasmodial activity of Ailanthus excelsa.
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pubmed:affiliation |
Department of Pharmacological Sciences, University of Milan, Milan, Italy. mario.dellagli@unimi.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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