Linked Life Data

18166224

Source:http://linkedlifedata.com/resource/pubmed/id/18166224

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2008-1-29
pubmed:abstractText
This work describes a two-step conjugate synthesis of a porous organometallic nanostructured materials composed of ferrocenemonocarboxylic (Fc-COOH) and 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA) and then a reagentless amperometric immunosensor prepared with positively charged gold nanoparticles (PGN) immobilized in this nanostructure conductive film is developed. This nanostructured material containing ferrocenyl (PTC-Fc) could easily form stable film on the electrode surface with efficient redox-activity and excellent conductivity. Furthermore, with the negatively charged surface, this film can be used as an interface to adsorbing the PGN, which was prepared in organic solvents at relatively high concentrations with improved monodispersity compared to those prepared in aqueous solution. The presence of PGN provided a congenial microenvironment for adsorbed biomolecules and decreased the electron-transfer impedance. Thus, with carcinoembryonic antibody (anti-CEA) as a model antibody, the proposed immunosensor showed rapid and highly sensitive amperometric response to carcinoembryonic antigen (CEA) with acceptable preparation reproducibility and stability.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0142-9612
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1501-8
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Nanostructured conductive material containing ferrocenyl for reagentless amperometric immunosensors.
pubmed:affiliation
Key Laboratory of Analytical Chemistry (Chongqing), College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't