|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2008-2-1
|
|
pubmed:abstractText |
Recent studies suggest that chloroquine resistance is mediated by an energy-dependent saturable chloroquine efflux carrier. An alternative explanation is that resistance is mediated by a channel. In Guinea-Bissau high doses of chloroquine are effective, well-tolerated and commonly used. This suggests that chloroquine resistance can be overcome by higher doses. Research on the mechanism of chloroquine resistance is of utmost importance and should include the effect of higher doses.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1471-4922
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
24
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
49-51
|
|
pubmed:meshHeading |
pubmed-meshheading:18165155-Animals,
pubmed-meshheading:18165155-Antimalarials,
pubmed-meshheading:18165155-Chloroquine,
pubmed-meshheading:18165155-Drug Resistance,
pubmed-meshheading:18165155-Guinea-Bissau,
pubmed-meshheading:18165155-Humans,
pubmed-meshheading:18165155-Ion Channels,
pubmed-meshheading:18165155-Malaria, Falciparum,
pubmed-meshheading:18165155-Membrane Transport Proteins,
pubmed-meshheading:18165155-Mutation,
pubmed-meshheading:18165155-Plasmodium falciparum,
pubmed-meshheading:18165155-Protozoan Proteins,
pubmed-meshheading:18165155-Treatment Outcome
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Carriers, channels and chloroquine efficacy in Guinea-Bissau.
|
|
pubmed:affiliation |
Malaria Research Unit, Department of Infectious Diseases, Karolinska Hospital, Stockholm, Sweden. johan.ursing@ki.se
|
|
pubmed:publicationType |
Journal Article
|
