Linked Life Data

18164200

Source:http://linkedlifedata.com/resource/pubmed/id/18164200

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-2-5
pubmed:abstractText
The use of doxorubicin (DOX) in the treatment of solid tumors is limited by cardiotoxicity essentially due to oxidative stress generation. The aim of this study was to identify coumarin derivatives displaying a protective antioxidant activity without affecting DOX antitumoral efficiency. A set of eighteen coumarinic derivatives was synthesized. Their antioxidant power was evaluated in vitro with the FRAP (ferric reducing ability of plasma) method and in human breast adenocarcinoma MCF7 cells using H(2)DCFDA (2',7'-dichlorodihydrofluorescein diacetate) in a cytometric analysis. 4-Methyl-7,8-dihydroxycoumarin was found to exhibit an important antioxidant strength, a low cytotoxicity, and could decrease ROS (reactive oxygen species) production generated by DOX treatment without affecting DOX cytotoxicity in MCF7 cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1464-3405
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1102-5
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Synthesis and protective effects of coumarin derivatives against oxidative stress induced by doxorubicin.
pubmed:affiliation
Laboratoire d'Ingénierie Moléculaire et Biochimie Pharmacologique, Université Paul Verlaine - Metz, Institut Jean Barriol FR CNRS 2843, UFR SciFA, Campus Bridoux, rue du Général Delestraint, 57070 Metz, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't