Linked Life Data

18162395

Source:http://linkedlifedata.com/resource/pubmed/id/18162395

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-2-5
pubmed:abstractText
Non-peptidic compounds containing the octahydro-indolo[4,3-fg]quinoline (ergoline) structural element have been optimized into derivatives with high affinity (pK(d) r sst(1)>9) and selectivity (>1000-fold for h sst(1) over h sst(2)-h sst(5)) for the somatostatin sst(1) receptor. In functional assays, these ergolines act as antagonists at human recombinant sst(1) receptors. Pharmacokinetic studies in rodents reveal good oral bioavailability and brain penetration for some of these compounds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1464-3405
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
979-82
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst 1 receptor.
pubmed:affiliation
Neuroscience Chemistry, Novartis Institutes for BioMedical Research, WSJ-088.3.06, CH-4002 Basel, Switzerland. thomas.troxler@novartis.com
pubmed:publicationType
Journal Article