Linked Life Data

18162218

Source:http://linkedlifedata.com/resource/pubmed/id/18162218

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Suppl 1
pubmed:dateCreated
2007-12-28
pubmed:abstractText
Over the last 25 years, allogeneic hematopoietic stem cell transplantation (HSCT) has been used increasingly as a curative treatment option for patients with hematologic and neoplastic diseases. Despite major advances in transplant immunology and improvements in supportive and critical care medicine, HSCT is still plagued by several life-threatening complications. As such, the establishment of effective therapeutic options for these complications will be crucial as increasing numbers of high-risk transplants are performed each year. This brief review will discuss the contribution of vascular endothelial cell activation and injury to inflammation and end-organ toxicity that occurs following allogeneic HSCT, and will highlight translational research efforts that have paved the way to the development of novel strategies to treat and prevent disease. Finally, we will discuss in detail the clinical manifestations and challenges encompassed by the syndrome of thrombotic microangiopathy following HSCT.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1523-6536
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-32
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The contribution of endothelial activation and injury to end-organ toxicity following allogeneic hematopoietic stem cell transplantation.
pubmed:affiliation
Blood and Marrow Transplantation Program, Case Comprehensive Cancer Center and Rainbow Babies and Children's Hospital, Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA. Kenneth.cooke@uhhospitals.org
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't