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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2007-12-27
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU234516,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU234517,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU234518,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU234519,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU234520,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU234521,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU234522,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU234523,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU234524,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU234525,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU234526,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU234527,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU234528,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU234529,
http://linkedlifedata.com/resource/pubmed/xref/GEO/GSE9317
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pubmed:abstractText |
The exosome complex plays a central and essential role in RNA metabolism. However, comprehensive studies of exosome substrates and functional analyses of its subunits are lacking. Here, we demonstrate that as opposed to yeast and metazoans the plant exosome core possesses an unanticipated functional plasticity and present a genome-wide atlas of Arabidopsis exosome targets. Additionally, our study provides evidence for widespread polyadenylation- and exosome-mediated RNA quality control in plants, reveals unexpected aspects of stable structural RNA metabolism, and uncovers numerous novel exosome substrates. These include a select subset of mRNAs, miRNA processing intermediates, and hundreds of noncoding RNAs, the vast majority of which have not been previously described and belong to a layer of the transcriptome that can only be visualized upon inhibition of exosome activity. These first genome-wide maps of exosome substrates will aid in illuminating new fundamental components and regulatory mechanisms of eukaryotic transcriptomes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arabidopsis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Exoribonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/MicroRNAs,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Untranslated,
http://linkedlifedata.com/resource/pubmed/chemical/RRP41 protein, Arabidopsis
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:AlonsoJoseJ,
pubmed-author:BelostotskyDmitry ADA,
pubmed-author:BrukhinVladimirV,
pubmed-author:ChekanovaJulia AJA,
pubmed-author:ChenHuamingH,
pubmed-author:EckerJoseph RJR,
pubmed-author:GregoryBrian DBD,
pubmed-author:GrossniklausUeliU,
pubmed-author:HookerTanyaT,
pubmed-author:KumarRaviR,
pubmed-author:LiPinghuaP,
pubmed-author:PengQianQ,
pubmed-author:ReverdattoSergei VSV,
pubmed-author:SkibaNikolaiN,
pubmed-author:YazakiJunshiJ
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1340-53
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pubmed:meshHeading |
pubmed-meshheading:18160042-Arabidopsis,
pubmed-meshheading:18160042-Arabidopsis Proteins,
pubmed-meshheading:18160042-Chromosome Mapping,
pubmed-meshheading:18160042-Exoribonucleases,
pubmed-meshheading:18160042-Gene Expression Profiling,
pubmed-meshheading:18160042-Gene Expression Regulation, Plant,
pubmed-meshheading:18160042-Genotype,
pubmed-meshheading:18160042-MicroRNAs,
pubmed-meshheading:18160042-Molecular Sequence Data,
pubmed-meshheading:18160042-Mutation,
pubmed-meshheading:18160042-Nuclear Proteins,
pubmed-meshheading:18160042-Nucleic Acid Conformation,
pubmed-meshheading:18160042-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:18160042-Peptide Mapping,
pubmed-meshheading:18160042-Phenotype,
pubmed-meshheading:18160042-Plants, Genetically Modified,
pubmed-meshheading:18160042-Proteomics,
pubmed-meshheading:18160042-RNA,
pubmed-meshheading:18160042-RNA, Messenger,
pubmed-meshheading:18160042-RNA, Small Interfering,
pubmed-meshheading:18160042-RNA, Untranslated,
pubmed-meshheading:18160042-RNA Interference,
pubmed-meshheading:18160042-Tandem Mass Spectrometry
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pubmed:year |
2007
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pubmed:articleTitle |
Genome-wide high-resolution mapping of exosome substrates reveals hidden features in the Arabidopsis transcriptome.
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pubmed:affiliation |
School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO 64110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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