Linked Life Data

18158096

Source:http://linkedlifedata.com/resource/pubmed/id/18158096

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-12-25
pubmed:abstractText
Aromatase P450 (P450(AROM)), converting testosterone (T) into estradiol (E), plays an important role in sexual differentiation of neural structures in the developing mammalian brain. The aim of the present study was to characterize the qualitative and quantitative profile of P450(AROM) mRNA expression in the bovine hypothalamus (the region of the central nervous system in which the enzyme is mainly localized) using RT-PCR and quantitative real-time RT-PCR analysis, respectively. P450(AROM) expression was examined in the developing hypothalamus in a series of experimental groups investigated at 10 weeks interval one from the other. Our data indicate that in the bovine fetal hypothalamus P450(AROM) expression peaks at the second quarter of gestation. The presence of neural cells containing P450(AROM) in the bovine fetal hypothalamus was confirmed by immunohistochemistry, and localized in the medial preoptic area. We conclude that second quarter of the gestation is the developmental stage which represents a critical period for hypothalamic differentiation in bovine ontogenesis, an important difference with the rat and mouse, short gestation species in which P450(AROM) activity peaks around delivery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
60-5
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Ontogenesis of brain aromatase P450 expression in the bovine hypothalamus.
pubmed:affiliation
Department of Experimental Veterinary Science, University of Padova, viale dell'Università 16, 35020 Legnaro (PD), Agripolis, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't