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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-12-24
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pubmed:abstractText |
The general anesthetic etomidate acts via gamma-aminobutyric acid type A (GABA(A)) receptors, enhancing activation at low GABA and prolonging deactivation. Azi-etomidate is a photo-reactive etomidate derivative with similar pharmacological actions, which has been used to identify putative binding sites. The authors examine the irreversible effects of azi-etomidate photo-modification on functional GABA(A) receptors in cell membranes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-10545178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-11141082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-11600682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-11744750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-11796752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-12351715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-12475885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-12646036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-12814659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-13679430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-14343300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-14569028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-15016806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-15123543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-15146041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-15232301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-15791108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-15976219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-16269537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-17093081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-17108970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-17322875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-17412502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-2994524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-3729056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-7685123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-7753491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-8658597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-8783230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-9058604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-9138677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-9282957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-9380754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18156888-9523815
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1528-1175
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
103-12
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pubmed:dateRevised |
2011-9-16
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pubmed:meshHeading |
pubmed-meshheading:18156888-Anesthetics, General,
pubmed-meshheading:18156888-Animals,
pubmed-meshheading:18156888-Cell Line,
pubmed-meshheading:18156888-Etomidate,
pubmed-meshheading:18156888-Female,
pubmed-meshheading:18156888-Humans,
pubmed-meshheading:18156888-Ion Channel Gating,
pubmed-meshheading:18156888-Photic Stimulation,
pubmed-meshheading:18156888-Photoaffinity Labels,
pubmed-meshheading:18156888-Receptors, GABA-A,
pubmed-meshheading:18156888-Xenopus laevis
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pubmed:year |
2008
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pubmed:articleTitle |
Photo-activated azi-etomidate, a general anesthetic photolabel, irreversibly enhances gating and desensitization of gamma-aminobutyric acid type A receptors.
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pubmed:affiliation |
Department of Anesthesia & Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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