|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2008-1-21
|
|
pubmed:abstractText |
Despite having potent activity against actively replicating Mycobacterium tuberculosis, isoniazid has very limited activity against dormant bacilli. In order to investigate the lack of bactericidal activity of this drug under conditions leading to mycobacterial dormancy, we studied the transcriptional pattern of M. tuberculosis in different physiological states following exposure to isoniazid.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1460-2091
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
61
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
323-31
|
|
pubmed:meshHeading |
pubmed-meshheading:18156607-Animals,
pubmed-meshheading:18156607-Female,
pubmed-meshheading:18156607-Gene Expression Regulation, Bacterial,
pubmed-meshheading:18156607-Genes, Bacterial,
pubmed-meshheading:18156607-Humans,
pubmed-meshheading:18156607-Isoniazid,
pubmed-meshheading:18156607-Mice,
pubmed-meshheading:18156607-Mycobacterium tuberculosis,
pubmed-meshheading:18156607-Tuberculosis
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Altered expression of isoniazid-regulated genes in drug-treated dormant Mycobacterium tuberculosis.
|
|
pubmed:affiliation |
Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21231-1001, USA. petros@jhmi.edu
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
