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rdf:type |
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lifeskim:mentions |
umls-concept:C0001041,
umls-concept:C0027747,
umls-concept:C0030685,
umls-concept:C0391871,
umls-concept:C0549193,
umls-concept:C0596235,
umls-concept:C0680255,
umls-concept:C1280500,
umls-concept:C1283071,
umls-concept:C1963578,
umls-concept:C2348149,
umls-concept:C2587213,
umls-concept:C2828391
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pubmed:issue |
3
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pubmed:dateCreated |
1976-10-2
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pubmed:abstractText |
1. A study has been made of the effects of changing [Ca]O and [Mg]O on the binomial statistic parameters p and n that control the average quantal content (m) of the excitatory post-synaptic potential (e.p.s.p.) due to acetylcholine release at preganglionic nerve terminals. 2. When [Ca]O was increased in the range from 0-2 to 0-5 mM, p increased as the first power of [Ca]O whereas n increased as the 0-5 power of [Ca]O; when [Mg]O was increased in the range from 5 to 200 mM, p decreased as the first power of [Mg]O whereas n decreased as the 0-5 power of [Mg]O. 3. The increase in quantal release of a test impulse following a conditioning impulse was primarily due to an increase in n; the increase in quantal content of successive e.p.s.p.s in a short train was due to an increase in n and p, and the increase in n was quantitatively described in terms of the accumulation of a Ca-receptor complex in the nerve terminal. 4. The decrease in quantal content of successive e.p.s.p.s during long trains of impulses over several minutes was primarily due to a decrease in n. These results are discussed in terms of an hypothesis concerning the physical basis of n and p in the release process.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-1142178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-1151780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-13278890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-13449874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-13481883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-13526124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-14321493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-164536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-165285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-165286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-16992305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-171018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4147099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4153582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4296699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4323933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4333832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4335804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4348351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4348786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4358351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4358352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4365809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4366332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4405553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4545024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4650939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4683097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-4813212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-5016365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-5133953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/181562-6065887
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-3751
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
257
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
597-620
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pubmed:dateRevised |
2010-9-1
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pubmed:meshHeading |
pubmed-meshheading:181562-Acetylcholine,
pubmed-meshheading:181562-Animals,
pubmed-meshheading:181562-Calcium,
pubmed-meshheading:181562-Electrophysiology,
pubmed-meshheading:181562-Guinea Pigs,
pubmed-meshheading:181562-Magnesium,
pubmed-meshheading:181562-Motor Endplate,
pubmed-meshheading:181562-Neuromuscular Junction,
pubmed-meshheading:181562-Receptors, Drug,
pubmed-meshheading:181562-Statistics as Topic,
pubmed-meshheading:181562-Synaptic Transmission
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pubmed:year |
1976
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pubmed:articleTitle |
The effect of calcium ions on the binomial statistic parameters that control acetylcholine release at preganglionic nerve terminals.
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pubmed:publicationType |
Journal Article,
In Vitro
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