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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-2-5
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pubmed:abstractText |
A graftable LDV (Leu-Asp-Val) peptidomimetic molecule (B-c) has been prepared from 3-(5-amino-2-hydroxy)phenyl-propionic acid, as alpha(4)beta(1) (VLA-4) integrin ligand. For that purpose, the mechanism of 3-(4-azidophenyl)propionic acid rearrangement has been revisited. Activation of Durapore DVPP-hydrophilic membrane, by surface wet chemistry using triazine trifluoride, followed by covalent coupling of B-c produced a modified filter (0.8% of derivatisation from XPS analysis) with improved capacity of leukocyte retention.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1084-90
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pubmed:meshHeading |
pubmed-meshheading:18155910-Amino Acid Sequence,
pubmed-meshheading:18155910-Drug Design,
pubmed-meshheading:18155910-Humans,
pubmed-meshheading:18155910-Integrin alpha4beta1,
pubmed-meshheading:18155910-Leukocytes,
pubmed-meshheading:18155910-Membranes, Artificial,
pubmed-meshheading:18155910-Molecular Mimicry,
pubmed-meshheading:18155910-Molecular Structure,
pubmed-meshheading:18155910-Oligopeptides,
pubmed-meshheading:18155910-Phenylpropionates,
pubmed-meshheading:18155910-Polyvinyls,
pubmed-meshheading:18155910-Structure-Activity Relationship
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pubmed:year |
2008
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pubmed:articleTitle |
A graftable LDV peptidomimetic: design, synthesis and application to a blood filtration membrane.
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pubmed:affiliation |
Unité de Chimie Organique et Médicinale, Université catholique de Louvain, 1 place Louis Pasteur, B-1348 Louvain-la-Neuve, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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