Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-12-24
pubmed:abstractText
GD3, a ganglioside expressed on melanoma, is the only tumour-associated glycolipid described to date that can induce a CD1d-restricted natural killer T (NKT)-cell response. We analysed the fine specificity of GD3-reactive NKT cells and discovered that immunization with GD3 induced two populations of GD3-reactive NKT cells. One population was CD4+ CD8- and was specific for GD3; the other population was CD4- CD8- and cross-reacted with GM3 in a CD1d-restricted manner, but did not cross-react with GM2, GD2, or lactosylceramide. This indicated that the T-cell receptors reacting with GD3 recognize glucose-galactose linked to at least one N-acetyl-neuraminic acid but will not accommodate a terminal N-acetylgalactosamine. Immunization with GM2, GM3, GD2, or lactosylceramide did not induce an NKT-cell response. Coimmunization of GM3-loaded antigen-presenting cells (APCs) with GD3-loaded APCs suppressed the NKT-cell response to GD3 in a CD1d-restricted manner. This suppressive effect was specific for GM3 and was a local effect lasting 2-4 days. In vitro, GM3-loaded APCs also suppressed the interleukin-4 response, but not the interferon-gamma response, of NKT cells to alpha-galactosylceramide. However, there was no effect on the T helper type 2 responses of conventional T cells. We found that this suppression was not mediated by soluble factors. We hypothesize that GM3 induces changes to the APC that lead to suppression of T helper type 2-like NKT-cell responses.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-10714687, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-11154912, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-11196188, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-12032173, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-12060764, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-12646609, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-12707346, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-12796469, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-12847141, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-14993837, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-15051763, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-15243159, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-15539565, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-15556688, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-15665086, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-15791257, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-15791258, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-15915536, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-16007091, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-16210594, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-16651387, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-17150027, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-17372206, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-17372214, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-2731184, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-3079806, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-4090532, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-6448893, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-7520467, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-7538697, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-9323206, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-9488653, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-9578432, http://linkedlifedata.com/resource/pubmed/commentcorrection/18154620-9857052
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1365-2567
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
123
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-55
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Fine specificity of natural killer T cells against GD3 ganglioside and identification of GM3 as an inhibitory natural killer T-cell ligand.
pubmed:affiliation
Department of Medicine, Swim Across America Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural