18154465

Source:http://linkedlifedata.com/resource/pubmed/id/18154465

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0033161, umls-concept:C0178784, umls-concept:C0805586, umls-concept:C1555307
pubmed:issue	1
pubmed:dateCreated	2007-12-24
pubmed:abstractText	Organ printing or biomedical application of rapid prototyping, also defined as additive layer-by-layer biomanufacturing, is an emerging transforming technology that has potential for surpassing traditional solid scaffold-based tissue engineering. Organ printing has certain advantages: it is an automated approach that offers a pathway for scalable reproducible mass production of tissue engineered products; it allows a precised simultaneous 3D positioning of several cell types; it enables creation tissue with a high level of cell density; it can solve the problem of vascularization in thick tissue constructs; finally, organ printing can be done in situ. The ultimate goal of organ-printing technology is to fabricate 3D vascularized functional living human organs suitable for clinical implantation. The main practical outcomes of organ-printing technology are industrial scalable robotic biofabrication of complex human tissues and organs, automated tissue-based in vitro assays for clinical diagnostics, drug discovery and drug toxicity, and complex in vitro models of human diseases. This article describes conceptual framework and recent developments in organ-printing technology, outlines main technological barriers and challenges, and presents potential future practical applications.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101278116
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	1746-076X
pubmed:author	pubmed-author:DrakeChristopherC, pubmed-author:KasyanovVladimirV, pubmed-author:MarkwaldRoger RRR, pubmed-author:MironovVladimirV
pubmed:issnType	Electronic
pubmed:volume	3
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	93-103
pubmed:dateRevised	2009-11-3
pubmed:meshHeading	pubmed-meshheading:18154465-Biotechnology, pubmed-meshheading:18154465-Humans, pubmed-meshheading:18154465-Reproducibility of Results, pubmed-meshheading:18154465-Robotics, pubmed-meshheading:18154465-Tissue Engineering
pubmed:year	2008
pubmed:articleTitle	Organ printing: promises and challenges.
pubmed:affiliation	Medical University of South Carolina, Department of Cell Biology and Anatomy, Charleston, South Carolina, USA. mironovv@musc.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't