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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1977-8-12
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pubmed:abstractText |
1. GTP and GMP-P(NH)P (guanyl-5'-yl imidodiphosphate) were observed to increase the stimulation of neural adenylate cyclase by dopamine (3,4-dihydroxyphenethylamine) and noradrenaline. 2. GMP-P(NH)P had a biphasic effect on the enzyme activity. 3. Preincubation of membranes with GMP-P(NH)P activated the enzyme by a process dependent on time and temperature. Catecholamines increased the speed and the extent of this activation. 4. Membrane fractions contained high- and low-affinity sites for GMP-P(NH)P binding: this binding was due to protein(s) of the membrane preparations. 5. Low-affinity-site binding of GMP-P(NH)P appeared to be related to the stimulatory effect on the adenylate cyclase activity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-1057166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-10890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-10895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-1120776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-1126949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-1186917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-13061491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-166994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-236641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-4149993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-4268121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-4326768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-4367725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-4376216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18147-820343
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-74
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18147-Adenosine Triphosphate,
pubmed-meshheading:18147-Adenylate Cyclase,
pubmed-meshheading:18147-Animals,
pubmed-meshheading:18147-Binding Sites,
pubmed-meshheading:18147-Caudate Nucleus,
pubmed-meshheading:18147-Cerebral Cortex,
pubmed-meshheading:18147-Dopamine,
pubmed-meshheading:18147-Drug Synergism,
pubmed-meshheading:18147-Guanine Nucleotides,
pubmed-meshheading:18147-Guanosine Triphosphate,
pubmed-meshheading:18147-Hydrogen-Ion Concentration,
pubmed-meshheading:18147-Magnesium,
pubmed-meshheading:18147-Male,
pubmed-meshheading:18147-Norepinephrine,
pubmed-meshheading:18147-Rats,
pubmed-meshheading:18147-Stimulation, Chemical,
pubmed-meshheading:18147-Subcellular Fractions,
pubmed-meshheading:18147-Time Factors
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pubmed:year |
1977
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pubmed:articleTitle |
Catecholamine-sensitive adenylate cyclase of caudate nucleus and cerebral cortex. Effects of guanine nucleotides.
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pubmed:publicationType |
Journal Article
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