Linked Life Data

1814566

Source:http://linkedlifedata.com/resource/pubmed/id/1814566

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1992-6-23
pubmed:abstractText
We examined the effects of electric stimulation of the cerebellar lateral nucleus (LN) in the rat on the activity of single pontocerebellar neurons in the basilar pontine nuclei (BPN) and the reticulotegmental nucleus (RtTg). We found that about half of the cells of these nuclei that were influenced by LN stimulation were inhibited. A significant fraction of both excitatory and inhibitory responses had latencies of less than 4 ms and were able to follow high frequency stimulation, compatible with a monosynaptic linkage. Extracellular field potential recordings within the BPN and RtTg were interpreted as arising from impulses propagating along inhibitory axons projecting in a bundle from the cerebellum to these pontine structures. Microiontophoretic administration of GABA antagonists bicuculline or picrotoxin abolished or attenuated most inhibitory effects. Therefore, we conclude that LN-induced inhibition is most likely mediated by cerebellopontine GABAergic fibers. The functional significance of this cerebellopontine inhibitory circuit is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
568
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
178-84
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
The cerebellopontine system: an electrophysiological study in the rat.
pubmed:affiliation
Institute of Human Physiology, University of Catania, Italy.
pubmed:publicationType
Journal Article