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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-6-22
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pubmed:abstractText |
To reduce the cost of treatment in renal transplant patients, ketoconazole, an inhibitor of the cytochrome P-450 enzyme system, was added to their triple immunosuppressive treatment (prednisone, azathioprine and cyclosporine). Thirty seven patients were included; they received 100-200 mg/day of ketoconazole and the amount of cyclosporine given was adjusted to keep its whole blood concentration within a therapeutic range. The dose of cyclosporine was decreased 70.4% by the first month of combined treatment and 76% by the ninth month. The benefit obtained with this reduction allowed the use of cyclosporine to be extended to all the patients and to administer it permanently. In 3 patients the increase in the serum hepatic enzymes made us stop ketoconazole. In order to detect hepatotoxicity early, periodic monitoring of liver function tests is mandatory.
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pubmed:language |
spa
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0535-5133
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
115-21
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1814474-Adolescent,
pubmed-meshheading:1814474-Adult,
pubmed-meshheading:1814474-Azathioprine,
pubmed-meshheading:1814474-Biotransformation,
pubmed-meshheading:1814474-Cyclosporine,
pubmed-meshheading:1814474-Cytochrome P-450 Enzyme System,
pubmed-meshheading:1814474-Drug Therapy, Combination,
pubmed-meshheading:1814474-Drug-Induced Liver Injury,
pubmed-meshheading:1814474-Female,
pubmed-meshheading:1814474-Humans,
pubmed-meshheading:1814474-Immunosuppression,
pubmed-meshheading:1814474-Ketoconazole,
pubmed-meshheading:1814474-Kidney Diseases,
pubmed-meshheading:1814474-Kidney Transplantation,
pubmed-meshheading:1814474-Liver Function Tests,
pubmed-meshheading:1814474-Male,
pubmed-meshheading:1814474-Middle Aged,
pubmed-meshheading:1814474-Prednisone
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pubmed:year |
1991
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pubmed:articleTitle |
[Usefulness of ketoconazole combined with cyclosporin in renal transplantation].
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|
pubmed:affiliation |
Servicio de Nefrología, Hospital Universitario, Universidad del Zulia, Maracaibo, Venezuela.
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pubmed:publicationType |
Journal Article,
English Abstract
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