Linked Life Data

1814312

Source:http://linkedlifedata.com/resource/pubmed/id/1814312

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-4
pubmed:dateCreated
1992-6-22
pubmed:abstractText
CD-1 strain, female mice, aged 5 to 7 months, were mated with males of the same age. Females presenting vaginal plug were separated and randomly distributed in two groups to be treated from the 6th to 17th day of gestation. One group received single daily diazepam doses (2.7 mg/kg i.p.), the other, 0.9% saline in equivalent volumes. Females were killed on 18th day, the placentas removed and fixed in 10% formaldehyde, pH 7.3, dehydrated and embedded in paraplast; 3 microns thick sections were stained with hematoxylin-eosin and Weigert hematoxylin and analyzed under light microscopy. Placentas of the diazepam-treated females presented dilated chorion vessels and intervillous spaces. Trophoblastic cell nuclei presented chromatin in coarse granules, atypically distributed in the karyolymph, which had lesser staining affinity. Giant cells showed vacuolized cytoplasm and coarsely granulated chromatin. Results indicate that diazepam causes structural changes, possibly placental and fetal physiology.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0067-9666
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-7
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:articleTitle
Diazepam effect upon the microscopic structure of the mouse placenta.
pubmed:affiliation
Department of Embriology, Facultad de Medicina, Universidad Nacional Autónoma de México, D.F.
pubmed:publicationType
Journal Article