Linked Life Data

1813984

Source:http://linkedlifedata.com/resource/pubmed/id/1813984

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4 Pt 1
pubmed:dateCreated
1992-6-17
pubmed:abstractText
Evaluating the response of animals to a toxic or therapeutic agent requires the knowledge of the dose of the agent in the respiratory tract. Dose is the amount retained in the lungs. It is the difference between the amount deposited and the amount cleared. Many factors influence the amount of and the site of deposition in the respiratory tract. For particles, the characteristics of the aerosol, most importantly size, the physiology of the animal, most importantly breathing pattern, and the geometry of the respiratory tract all play a role in determining local dose. These factors and their relative importance in determining regional deposition are discussed. Finally, ways in which dose can be measured in the respiratory tract are explored. These range from simple estimates of total dose using whole lung digests to the precise localization of dose in well-defined lung compartments using morphometry or in cellular or subcellular compartments using electron energy loss spectroscopy. The techniques utilized by an investigator depend on the amount of resolution desired. Their use and implementation in inhalation studies are the key to fully understanding the response of an animal to an inhaled toxic or therapeutic agent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0192-6233
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
384-97
pubmed:dateRevised
2009-7-1
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Pulmonary deposition: determinants and measurement techniques.
pubmed:affiliation
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusettes 02115.
pubmed:publicationType
Journal Article, Review