Linked Life Data

1813783

Source:http://linkedlifedata.com/resource/pubmed/id/1813783

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-6-16
pubmed:abstractText
Hyperparathyroidism is recognized to be an invariable complication of chronic renal insufficiency. Biochemical and/or histological evidence of hyperparathyroidism occurs in many patients with mild renal insufficiency (glomerular filtration rate of 50-75 ml/min) and predictably so when the glomerular filtration rate is less than 40-50 ml/min. A reduction in the serum concentration of 1,25-dihydroxyvitamin D, the biologically active metabolite of vitamin D, can contribute to the pathogenesis of the hyperparathyroidism, at least in part, by decreasing gut absorption of calcium and by increasing the set point for calcium suppression of parathyroid hormone release. In patients with mild and moderate renal insufficiency, both the serum concentration of 1,25-dihydroxyvitamin D and that of immunoreactive parathyroid hormone are importantly determined by the dietary intake of phosphorus. The pathogenesis of secondary hyperparathyroidism in patients with severe renal insufficiency is complex and multifactorial.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0378-0392
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-20
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Pathogenesis of secondary hyperparathyroidism in chronic renal insufficiency.
pubmed:affiliation
Department of Pediatrics, University of California, San Francisco.
pubmed:publicationType
Journal Article, Review