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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1992-6-12
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pubmed:abstractText |
Protein A is a cell wall linked protein of Staphylococcus aureus that binds mammalian IgG. Although protein A displays high size heterogeneity among strains, cloning and sequencing of its gene from two strains had not shown a large difference in size. Here we report a third protein A gene sequence that shows a size variation relative to these two, due to deletions on both one IgG binding domain and a cell wall binding domain (region X). By analysis of the three sequences we were able to delineate a hypothetic model for region X domain evolution and discussed the origin of genetic variability within and without strains.
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pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0233-111X
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
31
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
337-45
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:1813622-Amino Acid Sequence,
pubmed-meshheading:1813622-Base Sequence,
pubmed-meshheading:1813622-Binding Sites,
pubmed-meshheading:1813622-Biological Evolution,
pubmed-meshheading:1813622-Cloning, Molecular,
pubmed-meshheading:1813622-Genetic Variation,
pubmed-meshheading:1813622-Immunoglobulin G,
pubmed-meshheading:1813622-Molecular Sequence Data,
pubmed-meshheading:1813622-Mutation,
pubmed-meshheading:1813622-Restriction Mapping,
pubmed-meshheading:1813622-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1813622-Staphylococcal Protein A,
pubmed-meshheading:1813622-Staphylococcus aureus
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pubmed:year |
1991
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pubmed:articleTitle |
Nucleotide sequence of a variant protein A of Staphylococcus aureus suggests molecular heterogeneity among strains.
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pubmed:affiliation |
Ludwig Institute for Cancer Research, São Paulo Branch, Brasil.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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