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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1992-6-16
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pubmed:abstractText |
The aim of the study was to evaluate the efficacy of 5-aminosalicylic acid (5-ASA) in maintaining the remission in patients with inactive Crohn's disease over a period of three years, using either the Crohn's Disease Activity Index (CDAI) and or the Laboratory Index (LI). Thirty-eight patients entered in the study; 20 received 5-ASA 1.6 g/day and 18 no specific therapy. The patients were followed for three years. Of the patients, 86% presented a relapse, 80% in the 5-ASA group and 94% in the control group. Two patients requested surgical therapy. All patients with clinical relapse had CDAI greater than 150 and LI greater than 100. 5-Aminosalicylic acid was well tolerated and was able to protect from relapse up to 60% of the patients in the first year of therapy. When treatment with 5-ASA is prolonged for periods longer than one year a progressive increase in the number of patients who present relapse can be observed, but of the 5-ASA group, 80% of relapses occurred in the three years whereas the control group showed 94% relapses at the end of the first year.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0251-1649
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
200-2
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1813439-Adult,
pubmed-meshheading:1813439-Aminosalicylic Acids,
pubmed-meshheading:1813439-Crohn Disease,
pubmed-meshheading:1813439-Female,
pubmed-meshheading:1813439-Humans,
pubmed-meshheading:1813439-Male,
pubmed-meshheading:1813439-Mesalamine,
pubmed-meshheading:1813439-Recurrence
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pubmed:year |
1991
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pubmed:articleTitle |
5-aminosalicylic acid in the prevention of relapses of Crohn's disease in remission: a long-term study.
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pubmed:affiliation |
Division of Gastroenterology, Unita Sanitaria Locale, Pisa, Italy.
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pubmed:publicationType |
Journal Article
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