Linked Life Data

1811905

Source:http://linkedlifedata.com/resource/pubmed/id/1811905

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1992-6-5
pubmed:abstractText
High--resolution two--dimension electrophoresis technique for protein with silver staining was used to characterise urinary high density lipoprotein (HDL)--apolipoproteins. Sequential ultracentrufugation method was used to isolate urinary lipoprotein particles of the same density as serum HDL. Immunostaining of electroblotted proteins further confirmed the presence of HDL--Apos in urine. HDL--Apolipoprotein A--1, A--11 and C were identified in urine of normal subjects, diabetic patients and patients with biopsy proven glomerular proteinuria. An in-house ELISA method was used to quantify urinary HDL--Apo A--1. Selectivity indices were also determined. A high degree of association was found between selectivity index and urinary HDL--Apo A--1 (r = 0.87) and also between HFL--APO A--1 loss/24 h and total protein loss/24 h (r = 0.91). This appear to indicate that HDL loss in urine was a function of glomerular selectivity. Urinary HDL--Apo A--1 levels were significantly raised in the patients with glomerular proteinuria (p less than 0.01). HDL--Apo A--1 levels appear to be a marker for glomerular proteinuria. Consistent with glomerular proteinuria serum lipids and protein loss were significantly higher in patients with glomerular proteinuria (p less than 0.001) but HDL--Cholesterol was lower (p less than 0.001).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0008-9176
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Urinary high density lipoprotein--a possible marker for glomerular proteinuria.
pubmed:affiliation
Department of Chemical Pathology, Medical School of Zimbabwe, Harare.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't