Linked Life Data

1811230

Source:http://linkedlifedata.com/resource/pubmed/id/1811230

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1992-6-2
pubmed:abstractText
In this study, influence of several formulation factors on the release kinetics of potassium chloride from directly compressed matrices are investigated. Formulations containing hydrophilic (methylcellulose, carbomer), plastic (polyvinyl chloride), and wax (glycerol palmitostearate) matrix materials at concentrations of 10, 15 and 20%, incorporated with potassium chloride as active ingredient and insoluble excipients were prepared and studied in vitro using the USP XXI/NF XVI rotating paddle method. Hardness had no markedly effect on the release characteristics of formulations except for wax matrix material formulation. Results of goodness of fit analysis applied to release data had shown that the release mechanism was described by the Higuchi diffusion controlled model. Positive deviations from Higuchi equation might be due to the erosion of gel layer. Analysis of in vitro release mechanisms indicated that the most suitable results were obtained by methylcellulose and glycerol palmitostearate.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0031-7144
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
792-5
pubmed:dateRevised
2007-1-29
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Factors affecting the formulation of sustained release potassium chloride tablets.
pubmed:affiliation
Hacettepe University, Faculty of Pharmacy, Pharmaceutical Technology Department, Ankara, Turkey.
pubmed:publicationType
Journal Article