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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1992-6-3
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pubmed:abstractText |
1. Six weeks following partial nephrectomy in rats, significant increases in serum urea nitrogen and serum creatinine concentration and a significant decrease in creatinine clearance were observed. 2. Measurement of systolic blood pressure by tail plethysmography indicated that animals that had undergone partial nephrectomy were hypertensive. 3. Compared to sham-operated animals, there were 4 fold increases in both urinary protein excretion and urinary endothelin excretion. 4. There was a significant correlation between urinary protein and urinary endothelin excretion (r = 0.77). There was also a correlation (r = 0.65) between urinary endothelin excretion and systolic blood pressure. 5. Plasma endothelin concentrations were not different in sham-operated and partially nephrectomized rats. 6. The data indicate that there is an increased renal endothelin production in rats with chronic renal failure.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-1647960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-1694075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-1990204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2000950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2002644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2010532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2012367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2074661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2104254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2139584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2176978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2194067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2201203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2451132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2536405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2656297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2660593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2709670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-2993362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810606-3059828
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
987-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1810606-Animals,
pubmed-meshheading:1810606-Blood Pressure,
pubmed-meshheading:1810606-Blood Urea Nitrogen,
pubmed-meshheading:1810606-Creatinine,
pubmed-meshheading:1810606-Endothelins,
pubmed-meshheading:1810606-Kidney Failure, Chronic,
pubmed-meshheading:1810606-Male,
pubmed-meshheading:1810606-Nephrectomy,
pubmed-meshheading:1810606-Proteinuria,
pubmed-meshheading:1810606-Radioimmunoassay,
pubmed-meshheading:1810606-Rats,
pubmed-meshheading:1810606-Rats, Inbred Strains
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pubmed:year |
1991
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pubmed:articleTitle |
Increased endothelin excretion in rats with renal failure induced by partial nephrectomy.
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pubmed:affiliation |
SmithKline Beecham Pharmaceuticals, Department of Pharmacology, King of Prussia, PA 19406-0939.
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pubmed:publicationType |
Journal Article
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