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rdf:type |
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lifeskim:mentions |
|
|
pubmed:issue |
2
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|
pubmed:dateCreated |
1976-9-2
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|
pubmed:abstractText |
The coronary-active drug 3-2-diethylaminoethyl)-4-methyl-7-(carbethoxy-methoxy)-2-oxo-1,2-chromene-hydrochloride (carbocromen, Intensain) is known to be an inhibitor of phosphodiesterase (PDE). After intravenous as well as after intraduodenal application of therapeutic doses carbocromen increases in vivo the cAMP-contents of the hearts of rats (by up to 30%) and dogs (up to 50%). This effect is dose related. Correlations between the pharmacokinetic properties and metabolic actions of carbocromen and its influence on the adenylcyclase system are discussed.
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pubmed:language |
ger
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0004-4172
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
200-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:181028-Animals,
pubmed-meshheading:181028-Blood Pressure,
pubmed-meshheading:181028-Chromonar,
pubmed-meshheading:181028-Coumarins,
pubmed-meshheading:181028-Cyclic AMP,
pubmed-meshheading:181028-Dogs,
pubmed-meshheading:181028-Dose-Response Relationship, Drug,
pubmed-meshheading:181028-Drug Synergism,
pubmed-meshheading:181028-Female,
pubmed-meshheading:181028-Heart,
pubmed-meshheading:181028-Heart Rate,
pubmed-meshheading:181028-Injections, Intravenous,
pubmed-meshheading:181028-Isoproterenol,
pubmed-meshheading:181028-Male,
pubmed-meshheading:181028-Myocardium,
pubmed-meshheading:181028-Phosphodiesterase Inhibitors,
pubmed-meshheading:181028-Rats,
pubmed-meshheading:181028-Stimulation, Chemical
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pubmed:year |
1976
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|
pubmed:articleTitle |
[The effect of carbocromen on cardiac cyclic adenosine-monophosphate].
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pubmed:publicationType |
Journal Article,
English Abstract
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