Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1992-5-28
pubmed:abstractText
Most studies on pharmacodynamic variables in vitro, including the postantibiotic effect (PAE), are performed at pH 7.4 in noncationic-supplemented media, a situation which may differ significantly from the true microenvironment in most infected foci. We studied the impact of five different pH levels (pH 5, 6, 7, 7.4, and 8) on the duration of the PAE, the MIC, and bactericidal activity. Acid pH was found to have in general a deleterious effect on the activity of aminoglycosides and ciprofloxacin against Escherichia coli and Pseudomonas aeruginosa, with the MIC being higher, the bactericidal rate being lower, and the PAE being shorter at pH 5 (and to a lesser extent at pH 6) than at more alkaline pH levels. Similar results were observed for imipenem against P. aeruginosa. The PAEs induced by ampicillin against E. coli and dicloxacillin against Staphylococcus aureus were not predictably dependent on the pH, whereas the PAEs induced by ciprofloxacin against S. aureus were longest at either end of the pH spectrum. The bactericidal activity of these agents was, however, pH dependent, being slower at acid pHs. The addition of 50 mg of Ca2+ and 20 mg of Mg2+ per liter of liquid medium at pH 7.4 did not affect the duration of the PAE. Since the pH in abscess cavities may be close to 5, these observations may be of importance for employment of the agents studied in closed or poorly drained infections.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810197-2680058, http://linkedlifedata.com/resource/pubmed/commentcorrection/1810197-2789493, http://linkedlifedata.com/resource/pubmed/commentcorrection/1810197-2941261, http://linkedlifedata.com/resource/pubmed/commentcorrection/1810197-3142350, http://linkedlifedata.com/resource/pubmed/commentcorrection/1810197-3164987, http://linkedlifedata.com/resource/pubmed/commentcorrection/1810197-3293524, http://linkedlifedata.com/resource/pubmed/commentcorrection/1810197-3578330, http://linkedlifedata.com/resource/pubmed/commentcorrection/1810197-408423, http://linkedlifedata.com/resource/pubmed/commentcorrection/1810197-415096, http://linkedlifedata.com/resource/pubmed/commentcorrection/1810197-6173015, http://linkedlifedata.com/resource/pubmed/commentcorrection/1810197-6698939, http://linkedlifedata.com/resource/pubmed/commentcorrection/1810197-6766293, http://linkedlifedata.com/resource/pubmed/commentcorrection/1810197-6795174, http://linkedlifedata.com/resource/pubmed/commentcorrection/1810197-7037727
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2617-24
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Impact of pH and cationic supplementation on in vitro postantibiotic effect.
pubmed:affiliation
Department of Internal Medicine, Borgarspitalinn, Reykjavik, Iceland.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't